[Continued] 6. SS-cleavable and pH-responsive Lipid Like Material (COATSOME® SS-Series)
• Degradation of COATSOME SS-OP
High degradable type COATSOME® SS-OP
SS-OP was completely degraded by addition of Glutathione.
• in vivo toxicity in comparison to a competitor lipid
In the hepatotoxicity marker, SS-Cleavable lipid clearly shows biological safety in comparison with non-cleavable lipid.
COATSOME® SS Series enables delivery of various compounds in vivo by features of its intracellular delivery ability and biosafety. SS Series particles can encapsulate pDNA, siRNA, mRNA and hydrophobic low molecular weight
compounds, and has been proven in delivery targeting tumor, spleen, lymph node and brain. In the following we will introduce hepatic siRNA delivery data, hepatic mRNA delivery data and lymphatic mRNA delivery data for RNA vaccine
application as examples.
Hepatic siRNA delivery
• Example of Application
Hepatic delivery of mRNA
• RNA/DNA vaccine
Successful stimulation of cytotoxic immune-response were observed after a single S.C. injection.