[Continued] 7. SS-cleavable and pH-responsive Lipid Like Material (COATSOME® SS-Series)
• Toxitity of the particles
Cytotoxicity of the particles
Toxicity of the particles in vivo
In vitro transfection applying non-cleavable lipid shows sharp decline of cell survival rate by increase of the dose concentration. On the other hand, applying SS-Cleavable lipid, high cell survival rate is kept even when the dose is increased up to 10 folds of general transfection condition. Further, in the hepatotoxicity marker, SS-Cleavable lipid clearly shows biological safety in comparison with non-cleavable lipid.