[Continued] 7. SS-cleavable and pH-responsive Lipid Like Material (COATSOME® SS-Series)

• Toxitity of the particles

   Cytotoxicity of the particles

 

   Toxicity of the particles in vivo

SS lipids toxicity in vivo

In vitro transfection applying non-cleavable lipid shows sharp decline of cell survival rate by increase of the dose concentration. On the other hand, applying SS-Cleavable lipid, high cell survival rate is kept even when the dose is increased up to 10 folds of general transfection condition. Further, in the hepatotoxicity marker, SS-Cleavable lipid clearly shows biological safety in comparison with non-cleavable lipid.

 

 

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