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3. PEG Phospholipids

PEG phospholipids can be applied to liposomal drug
formulations to prolong the half-life of plasma circulation in drugs. Coating of the liposomal surface with polyethylene glycol suppresses drug clearance in vivo by the reticuloendothelial system, thereby prolonging the half-life of the drug.
PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.


p34_Figure_PEG Phospholipids