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3. PEG Phospholipids

PEG phospholipids can be applied to liposomal drug
formulations to prolong the half-life of plasma circulation in drugs. Coating of the liposomal surface with polyethylene glycol suppresses drug clearance in vivo by the reticuloendothelial system, thereby prolonging the half-life of the drug.
PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.


p34_Figure_PEG Phospholipids


DSPE-PEG 2,000
N-(Carbonyl-methoxypolyethyleneglycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt

DSPE-2arm PEG 2,000
N-[Carbonyl-2’,3’-Bis(methoxypolyethyleneglycol 2000)]-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt *make-to-order 

DSPE-PEG 5,000
N-(Carbonyl-methoxypolyethyleneglycol 5000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt

DSPE-2arm PEG 5,000
N-[Carbonyl-2’,3’-Bis(methoxypolyethyleneglycol 5000)]-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt *make-to-order