3. PEG Phospholipids
PEG phospholipids can be applied to liposomal drug
formulations to prolong the half-life of plasma circulation in drugs. Coating of the liposomal surface with polyethylene glycol suppresses drug clearance in vivo by the reticuloendothelial system, thereby prolonging the half-life of the drug.
PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.