7.SS-cleavable and pH-responsive Lipid Like Material (COATSOME® SS-Series)
COATSOME® SS-series New
SS-cleavable and pH-responsive lipid-like material for gene delivery and nucleic acid delivery system
We developed COATSOME®SS-series for gene delivery and nucleic acid delivery system. COATSOME®SS-series mounts dual sensing motifs that can respond to the intracellular environment; tertiary amines responsive to an acidic compartment (endosome/lysosome) for membrane destabilization, and disuifide bonding that can be cleaved in reductive environment (cytosol).
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• Proof of concept
Membrane disruption in the cells
The particle composed COATSOME® SS-series is stable in serum, hence enzymatic degradation of pDNA was prevented by encapsulation. Also the particle composed of COATSOME® SS-series was effectively destabilized in the cytoplasmic environment.
*H. Akita et al., Adv. Healthcare Mater., 2, 1120-1125 (2013)