7.SS-cleavable and pH-responsive Lipid Like Material (COATSOME® SS-Series)

COATSOME® SS-series New

SS-cleavable and pH-responsive lipid-like material for gene delivery and nucleic acid delivery system

We developed COATSOME®SS-series for gene delivery and nucleic acid delivery system. COATSOME®SS-series mounts dual sensing motifs that can respond to the intracellular environment; tertiary amines responsive to an acidic compartment (endosome/lysosome) for membrane destabilization, and disuifide bonding that can be cleaved in reductive environment (cytosol).

 

        *products of above table are available online. please check the bottom of this page.

 

• Proof of concept

Particle formation

Serum resistance

Membrane disruption in the cells

The particle composed COATSOME® SS-series is stable in serum, hence enzymatic degradation of pDNA was prevented by encapsulation. Also the particle composed of COATSOME® SS-series was effectively destabilized in the cytoplasmic environment.

 

*H. Akita et al., Adv. Healthcare Mater., 2, 1120-1125 (2013)

 

 

 

 

Myristoyl MW:  717.2 100mg in amber glass bottle.

α-D-Tocopherolhemisuccinoyl MW:  1322.0 100mg in amber glass bottle.

α-D-Tocopherolhemisuccinoyl MW:  1402.2 100mg in amber glass bottle.