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Phospholipids and Lipids

NOF supplies high-purity phospholipids, phospholipid derivatives and liposomes from reagents to bulk in pharmaceuticals. Using the state-of-the-art synthesis and purification technology, we have developed various kinds and grades of products. Bulk phospholipids are produced in the facility under GMP operation and have been supplying worldwide for many years with a high reputation.

NOF supplies purified egg PC, egg PG, soy PC, hydrogenated soy PC and sphingomyelin for natural phospholipids.

Regarding synthetic phospholipids, DDPC, DLPC, DMPC, DPPC, DSPC, DOPC, POPC and DEPC are available in PC series. DMPG, DPPG, DSPG and POPG are available in PG series. DMPA, DPPA and DSPA are available in PA series. DMPE, DPPE, DSPE and DOPE are available in PE series. DOPS is available in PS series in stock. PEG or polyglycerin attached phospholipids (PG phospholipid) are available for long circulating liposome formulation.

Activated functional group attached phospholipids, either PEG end or non-PEG end, are also available for immunoliposome or targeting use liposome.

For non injectable use, DPPC, POPC and POPG are recommended for pulmonary delivery while DOPC, POPC and DDPC are recommended for nasal delivery.

We also offer custom-made synthesis of phospholipid and provide unique liposome research kits (Empty liposome) for drug delivery systems (DDS).

 

Capability

cGMP Manufacturing Facility
NOF Phospholipids are manufactured in facility under cGMP operation and have been supplied worldwide for many years with good reputation.
cGMP Manufacturing Facility


Drug Master File
NOF has already submitted 19 DMFs regarding many kinds of phospholipids to US FDA so that customers rely on our quality. We submit DMF according to customer's request and development.

DODAP
1,2-Dioleoyloxy-3-dimethylaminopropane [1g in amber glass bottle]


DOTAP
1,2-Dioleoyloxy-3-trimethylammonium propane chloride &nbsp[1g amber glass bottle]


DODMA
1,2-Dioleyloxy-3-dimethylaminopropane [1g in amber glass bottle]


DOTMA
1,2-Dioleyloxy-3-trimethylammonium propane chloride [1g in amber glass bottle]


DMPE-Glu
N-Glutaryl-L-α-phosphatidylethanolamine, Dimyristoyl
[1g amber glass bottle]


DMPE-MAL
N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Dimyristoy


DMPE-NHS
N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Dimyristoyl


DPPE-PDP
N-[3-(2-Pyridinyldithio)-1-oxopropyl]-L-α-phosphatidylethanolamine, Dipalmitoyl


DPPE-Glu
N-Glutaryl-L-α-phosphatidylethanolamine, Dipalmitoyl
[1g amber glass bottle]


DPPE-MAL
N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Dipalmitoyl


DPPE-NHS
N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Dipalmitoyl


POPE-Glu
N-Glutaryl-L-α-phosphatidylethanolamine, 1-Palmitoyl-2-oleoyl
[1g amber glass bottle]